Endocrine Abstracts

Two patients presented to us with polyuria and polydipsia.Case 1– A 34 year old gentleman was referred with polyuria, polydipsia, diffuse headaches and poor sleep. Initial plasma and urine osmolality were 306 and 272 milliosmol/kg respectively. Water deprivation test demonstrated normal concentrating ability. Starting urinary osmolality was 788 milliosmol/kg, rising to 877 milliosmol/kg. MRI pituitary was normal. Hypertonic saline infusion test prod...

An asymptomatic 66-year-old man was referred for investigation of chronic hypernatraemia. Plasma sodium varied between 146–152 mmol/l and potassium was normal over several years. There was no relevant past, family or drug history. There were no symptoms or signs of hypercotisolism or other endocrinopathy either. Clinical examination was normal.Initial investigations were as follows – sodium 149 mmol/l, potassium 4.3 mmol/l, urea 7.9 mmol/l, cre...